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KMID : 0360220220630010020
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Journal of the Korean Ophthalmological Society
2022 Volume.63 No. 1 p.20 ~ p.26
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Retinal Vascular Caliber Changes in Early Type 2 Diabetic Patients without Retinopathy
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Park Jeong-Woo
Bae Jeong-Hun
Song Su-Jeong
Kim Joon-Mo
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Abstract
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Purpose: To evaluate the retinal vascular caliber in early type 2 diabetic patients without retinopathy.
Methods: This retrospective study reviewed the medical records of 85 patients who were diagnosed with type 2 diabetes (age, 10-48 years) and sex-matched healthy controls. Dilated fundus examinations were performed to confirm the absence of diabetic retinopathy. Fundus photographs were acquired and analyzed using software that semi-automatically measured retinal vascular caliber. Central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and arteriovenous ratio (AVR) were determined using the revised Parr-Hubbard formula. Healthy controls were examined using the same approach.
Results: There were no significant differences between patients and controls in terms of CRAE (149.92 ± 21.29 μm and 144.85 ± 17.14 μm, respectively; p = 0.137) or CRVE (195.85 ± 22.94 μm and 196.69 ± 18.43 μm, respectively; p = 0.829). However, AVR was significantly higher in the patient group (0.768 ± 0.088 vs. 0.737 ± 0.061; p = 0.031). In the patient group, AVR was significantly correlated with hemoglobin A1c (r = 0.325, p = 0.006), but not with body mass index (p = 0.478).
Conclusions: An increase in peripapillary AVR may be an early feature of retinal vessels observed in patients with type 2 diabetes, which is closely related to elevated blood sugar.
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KEYWORD
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Arteriovenous ratio, Retinal vascular caliber, Type 2 diabetes
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